The dosage dance
Posted on | April 3, 2009 |
Vodka had Palladia again today. In the last week without Palladia, the tumor in his shoulder has grown bigger. Really sucks 
Especially since the unpredictable food response continues:
- He’s still picky - what works for one meal does not always work for another
- He drank tons of water right after he gobbled up food yesterday AM and ended up regurgitating some of it! Oy. Luckily that didn’t affect him any further - he continued to eat and drink and play the rest of the day.
- His poop isn’t back to being stellar.
The good thing is that he’s eaten well this last week in spite of it all - many thanks to Stephanie’s creative cooking! 
We’ve been talking about Palladia dosing with all of Vodka’s doctors - obviously, determining the right dose for him is still work in progress. We’ve now chosen to try the lower dose of Palladia (115 mg) every 72 hours (3 days). And we’re hoping to give him Metoclopramide (Reglan) over the course of a day right after the Palladia dose for protecting his GI system.
So, we’re continuing to fine-tune a multi-pronged strategy for coping with side effects here:
- 3 doses of Metoclopramide over the 24 hours after Palladia - for dealing with GI motility issues
- Metronidazole - for dealing with diarrhea
- Nux vomica - a homeopathic protocol for coping with nausea/vomiting
- Digestive soother - composed of slippery elm, l-glutamine and fructo-oligosaccharides for coating the stomach
- Carafate - for coating the stomach
- Tagamet - for protecting the stomach against histamine release
- Probiotics - essential for maintaining digestive flora
A couple more supplements I’ve ordered that will hopefully help here:
This is a predigested fish protein concentrate that has worked really well to alleviate symptoms of IBD and Crohn’s disease. An acquaintance on an animal cancer alias is a RN who works with human cancer patients - she’s apparently seem good results when chemo patients use Seacure for dealing with nausea and inappetance.
Clay is one of the most effective natural intestinal detox agents out there. Bentonite is the commercial name for montmorillonite clay (named after the region of France it was originally found in). Liquid Bentonite works well in flushing toxins from the intestinal system. Plus it is inert - a good thing since it just passes through the body undigested. Think of it as this giant sponge that harmlessly traverses the digestive system picking up all the irritants that need to be purged from the system.
The one potential downside is “flushing” of medicines. Clay works similar to activated charcoal - the timing of dosage needs to be played with to avoid flushing out essential nutrients and medicines from the body. So, we might need to give this to Vodka between meals, away from other meds that need to be properly absorbed into the system and have the clay focus on flushing out the stomach toxins instead.
2nd Metoclopramide dose - 3:30 AM (?!!). And another one 8 hours from now.
Photo Courtesy: Stephanie and Shawn (Dog-E-Central)
Keep those good wishes rolling!
Tags: bentonite > diarrhea > herbs > homeopathy > inappetance > nausea > Palladia > seacure > side effects
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4 Responses to “The dosage dance”
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April 7th, 2009 @ 9:17 pm
Your website seems like a gift from Heaven. Our Black Labrador, Han, was diagnosed with MCT almost one year ago and had surgery in August 2008 to remove it. After months of chemotherapy, Han had an ultrasound on February 11, 2009, which revealed the MCTs had spread to two of his lymphnodes - one in the abdomen region and one in his stomach. He began radiation and another round of chemotherapy which since has virtually caused the tumor to disappear and has caused the lymphnode in his abdomen area to shrink to almost nothing. However, he had a chest x-ray in March which revealed the MCTs had spread to lymphnodes in his chest. Our oncologist fought for him and got Han put on a clinical trial of Palladia. He’s been on it now for about three weeks, but the side effects are starting to become apparent. Han has lost his appetite but not a lot of weight. Today (April 7) we took him to see his oncologist because he wouldn’t eat. She did another chest x-ray and found that the lymphnodes in his chest had enlarged slightly, and that his red blood cell count was low (25%). We have had Han on Innova Evo as well and have been giving him a variety of vegetables and meat since August. I am glad to know that your dog, Vodka, is experiencing similar side effects (not glad but relieving to know there’s someone else out there with the same troubles) from the Palladia. We have wondered about giving Han immune boosters like K-9 Immunity, but were not sure. His oncologist seemed to be against it, and now that he started the Palladia we didn’t know if they would interact with his treatment. We live in Arizona. We had an appointment with Dr. Hershey, but Han started on the Palladia before he saw her and we canceled his appointment. Are there any suggestions you might give us about appetite, lethargy, bathroom problems? supplements? immune therapy? Thank you.
April 8th, 2009 @ 10:30 pm
Hey Billie Sue,
Am sorry to hear about Han’s MCTs - I really hope the Palladia works and things get better. I’m going to write a post now with our Palladia experiences and potential ways to alleviate the side effects - we don’t have the answers as yet, but are trying to find ways to make it a working solution.
Obviously, please send me email if you have more questions about our treatment protocols.
May 28th, 2009 @ 9:35 am
I have a friend whose dog has cancer and the friend would like to have Palladia to try on the dog. Who can we contact to try to get it?
August 29th, 2010 @ 7:46 pm
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